Last comic about The Final Station had Angie trampling some infected with a train... stuff like that doesn't happen in the game as far as I know, but many times when doing a comic it's more important to take the essence of the game than trying to emulate a game mechanic.

You have infected, you have trains, you have a badass machinist and you have to show it all in a single frame. My only regret is not making it the scene in tiny pixel art.